Since its original release, NUENDO s' is always installed.
Currently no incompatibility (version1.61)
Yes, whatever the sound card, ds that the latter is installed, everything is clear, the audio engine being diffrent Cubase, there is the flexibility and more.
The manual ... so the PDF is available in french and tlechargement.

SUITABILITY/PERFORMANCE

I use it on a PIII 1Ghz, 512 ram, motherboard ABIT BX133Raid, 2 ATA100 HDD IBM, RME96/52 (test and used with M-Audio DELTA 1010)
This software is a bomb, to record live with eyes closed!
Same for the monitoring through the VST mixer, 1.5 ms of latency, all the effects ....

OVERALL OPINION

I use NUENDO since its inception.
What I love most in this app: Audio Edition direct and rapid management Surround
the simplicity of automation. Its interface was simple Drout ... however it is the view and to work long ago not need fluorescent flashing icons ....
I do it again this choice no doubt, by the way if CUBASE SX as it is thanks to experience gained with NUENDO.