The configuration of the Line 6 Flextone 3 is pretty easy to follow and it won't take too long to understand what everything does. It does take a little bit of time to figure out how to navigate through the screen, but it is done smartly enough that it won't take too long. It is pretty easy to get a good sound from this amp, but it really depends on what type of sound you are going for, as some of the effects are better than other on this amp. The manual for the Line 6 Flextone 3 is pretty complete and easy to understand, and it is a good idea to have it around while learning this amp.
The Line 6 Flextone 3 is great for rock music, but will work in almost any setting. The effects range from delays and reverbs to modulation effects, but none of the effects are that impressive to me. This being said, they are usable and it is nice to have so many different types of effects within one amp. It has a great clean tone, but the distortion comes off a bit tinny sounding and I would recommend using a pedal for your overdrive when using this amp.
I've been using the Line 6 Flextone 3 for about a year and I have found it to be a good guitar amp. It isn't the best by any stretch, but it is a reasonably priced option for the intermediate player looking for an amp with effects. It is versatile and is perfect for the player looking to figure out what effects they like to use best. Overall, the Line 6 Flextone 3 is a nice amplifier, but I wouldn't recommend it for professionals in any situation.