I am currently running Ohm Force Predatohm on a Mac Book Pro that has a 2.2 Ghz Intel Core 2 Duo processor and 4 GB of RAM. I run the plug-in only in Pro Tools LE 7.4 that runs with a Digi 002R audio interface, and within the configuration I can't say I've ever had any problems running Predatohm. I'm able to run a bunch of them within a single session, but don't overdo it too often so I can't say that I would be able to run an endless amount of these plug-ins. I've been running the plug-in only for only a few months but it has become one of my favorite digital distortions to use in this short time.
I would definitely recommend checking out Ohm Force Predatohm if you are in the market for a good sounding distortion plug-in. While I don't tend to be a fan of digital distortions at all, this one has some really cool features and sounds. Beyond this plug-in, Ohm Force makes some great plug-ins and I would definitely recommend checking out the bundles that they have to offer as they are very reasonably priced and make each individual a lot cheaper. Also, if you are a student Ohm Force offers up a 50% discount! All in all, Ohm Force Predatohm is a powerful plug-in that should definitely be looked into by home and professional studio owners alike.