Yes, the Scarlett 6i6
can operate in a 'stand-alone' mode. You are required to save your Mix Control settings to the hardware whilst connected to your computer, once that is done, the 6i6 will operate stand-alone (i.e. not connected to your computer) with the Mix Control settings you have saved onto it.
I hope this answers your question.
Please don't hesitate to get in contact if you have other questions.
You may also find our product comparison chart handy, you can filter products by series too:
Simon // Focusrite Technical Support
[ Post last edited on 05/01/2014 at 07:06:34 ]