I have the Pro24DSP on Firmware version 2761, Saffire MixControl 3.7 running on Windows 10 64bit. Whenever Windows 10 comes back from a sleep or hibernation, there is no audio. I have to restart the computer to get the audio working again. I have tried powering the Pro24DSP off/on and/or unplug/plug the firewire cable and still no audio. I see that there is audio signal going through the Saffire Mix Control but no sound. There is also no audio through the headphone either.The computer does recognized the Pro24DSP otherwise there would be no audio signal going through the Saffire Mix Control and there would be an exclamation mark on the Safire in the Windows Device Manager or missing altogether. I believed it has been happening like this for a long time.
Instead of restarting you could try to alter the buffer size in the Focusrite MixControl software after wakeup. Let's say it sits on 512, you can set it to 1024... Check if there's sound now... You can then change it back to the desired size... It works for me, but is of course still annoying... But safes me a restart
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