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Scarlett 2i4 2nd gen. crackling when using two programs.

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Topic Scarlett 2i4 2nd gen. crackling when using two programs.
I've just made a new Windows 10 pc build with 32gb ram on an ASUS motherboard and an AMD Ryzen 9 3900x 12-core CPU.
The 2nd gen scarlett 2i4 I have works very well with Cubase when I'm making music.
But I run into trouble if I have to work with Guitar Pro 7.5 using RSE sounds and using a guitar sim like S-Gear or Guitar Rig at the same time. I have to set the buffer really high to get around this, making the works process harder due to latency issues.
What can I do?

Thanks a lot.